The US Africa Command (Africom) confirmed to the Associated Press Sunday that the airstrike was launched near al-Bur, according to various reports on Monday.
A vehicle carrying senior officials with the al-Shabab militant group was reportedly targeted and a woman was among the dead.
While the militant group has not officially commented on the report, media outlets close to al-Shabab reported that two civilians were killed.
The US, meanwhile, claimed that no civilians were killed in the strike.
The US carries out its first strikes against purported Daesh positions in Somalia as it steps up its military campaign across Africa.
Since last year when President Donald Trump approved expanded military efforts against the group, the US military has launched more than a dozen drone strikes against it.
Washington claims that it coordinates such drone strikes with the Somali government.
There has been a sharp rise in the number of US drone strikes around the world since Trump took office, according to a report published in December by the Bureau of Investigative Journalism.
The US carries out drone attacks in Yemen and several other Islamic countries, claiming to be targeting al-Qaeda elements. However, local sources say civilians have been the main victims of the attacks.
American technology giant Google has allowed the US Defense Department to utilize its artificial intelligence (AI) technologies in military drone projects, stirring concern among experts who think such cooperation is not ethical.
By Africafrique and agencies